PAW Hepatoadvanced Medium and Large Dog 30 Tablets

The PAW Hepatoadvanced Formula promotes liver detoxification in cats and small dogs. This antioxidant supplement helps manage liver biomarkers that are compromised. To determine your pet's needs, a veterinarian's opinion is recommended before and during the use of this product.

The Key Benefits of PAW Hepatoadvanced Medium and Large Dog 30 Tablets

• It contains a stable form of S-adenosyl-L-methionine (SAMe), which is essential for transmethylation, transsulfuration, and aminopropylation pathways. Reduces cholestasis and regulates apoptosis by modulating cytokine expression

• With silybin in a phospholipid complex, this product is more bioavailable than standard milk thistle, increases biliary flow, inhibits leukotriene production, modifies membrane function (inhibits toxin binding), and restores antioxidant enzyme expression and activity.

• Provides cell proliferation, gene expression, and regulation of cell signalling pathways mediated by reactive oxygen intermediates thanks to vitamin E

Why Choose PAW Hepatoadvanced Medium and Large Dog 30 Tablets?

• Supports glutathione production
• Promotes detoxification of the liver 
• Helps to decrease the negative side effects of some medications on the liver
• Supports the liver in cases of acute liver toxicity
• Promotes proper brain function in dogs  
• Presented as a tasty, chewable tablet
• Simple and convenient dosing
• Formulated with delayed-release technology – promotes steady metabolism by the liver and a prolonged duration of activity

If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced.

Ingredients & Analysis

S-Adenosyl-L-methionine disulfate p-toluenesulfonate (equivalent to SAMe), D-alpha tocopherol succinate (Vitamin E), Silybin phospholipids (equivalent to silybin A+B), flavour, tablet diluents, binders and lubricants 

Hepatoadvanced may be used as adjunctive therapy in conditions such as:

• Chronic hepatitis
• Hepatic lipidosis
• Cholangiohepatitis
• Paracetamol toxicity
• Hepatotoxic mushroom ingestion
• Copper related hepatopathy
• Iron overload - Medication use including NSAIDs, phenobarbital and corticosteroids (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
• Metabolic hepatopathies
• Other acute or chronic hepatopathies
• Neoplasia
• Canine cognitive dysfunction
• Cirrhosis

How to Use PAW Hepatoadvanced Medium and Large Dog 30 Tablets

• Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
• Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome
• Safe use in pregnant or lactating animals has not been established

Typical Analysis

• DO NOT exceed 2 chewable tablets per day
• If your pet is currently taking behavioural medication, please consult your vet before using Hepatoadvanced
• For optimal absorption, administer Hepatoadvanced (as per the dosing chart), once a day on an empty stomach
• A tablet may be broken in half but do not crush
• The recommended total daily dose for dogs and cats: S-adenosyl-L-methionine (sAMe): 10- 20mg/kg, SPC 2.7- 5.4mg/kg and vitamin E 10-15IU/kg
• Hepatoadvanced can be used alongside other hepatic treatments, such as prescription diets, ursodeoxycholic acid, anti-inflammatories, and other non-vitamin E containing nutritional supplements
• Your veterinarian should advise the duration of treatment 
• Regular re-assessment (eg. every 1-3 months) is recommended to ensure the optimal dose is achieved to reach the desired therapeutic outcome

Recommended Daily Dose 

Note:

• For animal use only
• For veterinary supply only
• Use with caution in pregnant or lactating animals as safe use has not been established

The Side Effects of the Active Ingredients

SAMe

• There is a wide margin of safety for SAMe

• Mild gastrointestinal signs, nausea and food refusal are the most common side effects or overdose effects.

• It has been suggested that concomitant use of SAMe with tramadol, meperidine, dextromethorphan, pentazocine, MAOIs (selegiline), SSRIs (fluoxetine), as well as other antidepressants (amitriptyline, clomipramine) may have additive effects on serotonin levels.

• When used simultaneously, proceed with caution

Silymarin

• Generally, silymarin does not cause side effects but considers drug interactions in polymedical patients, such as antiviral drugs, anti-CYP3A4 inhibitors and drugs cleared by hepatic glucuronidation.

Vitamin E

• When administered at high doses, vitamin E may prevent the absorption of other fat-soluble vitamins, but no toxic effects have been reported.

• In order to prevent overdosing, the recommended total daily dose per dog should not exceed 400IU

• Patients with liver disease and vitamin K deficiency are not recommended to take vitamin E